R/draw_parameters_options.R
draw_parameters_fixed_fx_biomarker_dep.RdAdds biomarker quantity ceiling effects to the draw_parameters_fixed_fx function. Here, an individual’s realized biomarker boost is dependent on their biomarker quantity at the time of the exposure event.
draw_parameters_fixed_fx_biomarker_dep(
i,
t,
x,
demography,
biomarker_states,
model_pars,
...
)individual
time
exposure
demography information
an array of true biomarker quantities for all individuals across all time steps and biomarkers
tibble of biomarker (antibody) kinetics parameters with variables: 1) exposure_id: numeric exposure ID; 2) biomarker_id: numeric biomarker ID; 3) name: the character name of the parameter; 4) mean: numeric mean of this parameter distribution; 5) sd: the numeric standard deviation of the parameter distribution; 6) distribution: character description of the parameter distribution type (e.g., log-normal, normal)
Additional arguments
A tibble with the simulated parameters for this exposure event
model_pars <- reformat_biomarker_map(example_model_pars_biphasic)
draw_parameters_fixed_fx_biomarker_dep(2,100,1,example_demography,
example_biomarker_states_wide, model_pars)
#> # A tibble: 8 × 7
#> i t x b name value realized_value
#> <dbl> <dbl> <dbl> <dbl> <chr> <dbl> <dbl>
#> 1 2 100 1 1 boost_long 0.5 0.0500
#> 2 2 100 1 1 boost_short 0.25 0.0250
#> 3 2 100 1 1 wane_long 0.01 0.01
#> 4 2 100 1 1 wane_short 0.033 0.033
#> 5 2 100 1 1 biomarker_ceiling_threshold 1.7 1.7
#> 6 2 100 1 1 biomarker_ceiling_gradient 0.529 0.529
#> 7 2 100 1 1 biomarker_prot_midpoint 0.075 0.075
#> 8 2 100 1 1 biomarker_prot_width 0.1 0.1